Cerebral cortex neuron differentiation

Across TCGA patient cohorts, RNA activity of the Cerebral cortex neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRPSAP2, ADAMTSL2, and PURA_S256, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex neuron differentiation activity versus PRPSAP2 in COAD (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PRPSAP2 →	+0.201	+0.033	.001	.005	3	4
PDAC	ADAMTSL2 →	-0.932	-0.070	<.001	<.001	3	4
UCEC	PURA_S256 →	-0.415	-0.058	<.001	.008	3	4
GBM	CRYBG1_S103 →	-0.993	-0.106	.001	.002	3	4
GBM	ALOX5 →	-0.635	-0.063	<.001	<.001	3	4
GBM	PIK3AP1 →	-0.467	-0.053	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021895 vs PRPSAP2 — COAD

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