Cerebral cortex neuron differentiation

Across TCGA patient cohorts, RNA activity of the Cerebral cortex neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-16P, H3P14, and HIKESHI, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex neuron differentiation activity versus RNU6-16P in HNSC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-16P →	+2.056	+0.570	<.001	<.001	3	5
HNSC	H3P14 →	+1.354	+0.529	<.001	.007	3	4
LSCC	HIKESHI →	+0.235	+0.392	.001	.002	3	4
COAD	TCAP →	+0.280	+0.497	.002	.009	3	3
COAD	HMGB1P37 →	+0.457	+0.627	.002	.005	3	3
COAD	RPL31P7 →	+0.398	+0.622	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021895 vs RNU6-16P — HNSC

Explore this scatter interactively →