Cerebral cortex neuron differentiation

Across TCGA cell cohorts, RNA activity of the Cerebral cortex neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTRC, BUD13, and ACTR1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex neuron differentiation activity versus BTRC in PANCREAS (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	BTRC →	+0.919	+1.106	.006	.007	3	4
BLOOD_Leukemia	BUD13 →	+0.600	+0.203	.001	.001	3	3
BLOOD_Leukemia	ACTR1A →	+0.546	+0.132	<.001	.007	3	3
BLOOD_Leukemia	FTO →	+0.630	+0.198	<.001	.001	3	3
BLOOD_Leukemia	U2AF1 →	+0.752	+0.184	.001	.004	3	3
PANCREAS	STAG2 →	+0.923	+1.134	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021895 vs BTRC — PANCREAS

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