Cerebral cortex GABAergic interneuron differentiation

Across TCGA patient cohorts, RNA activity of the Cerebral cortex GABAergic interneuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPNS2, USP9X, and ZNF200, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex GABAergic interneuron differentiation activity versus CAPNS2 in GBM (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CAPNS2 →	+0.533	+0.678	.003	.002	2	4
UCEC	USP9X →	+0.611	+0.581	<.001	.003	3	3
UCEC	ZNF200 →	+0.498	+0.551	.003	<.001	3	2
UCEC	DHX15 →	+0.589	+0.463	.003	.001	3	2
GBM	RNU4-36P →	-0.695	-0.761	.005	<.001	3	2
LSCC	VPS33A →	-0.425	-0.299	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021892 vs CAPNS2 — GBM

Explore this scatter interactively →