Cerebral cortex GABAergic interneuron differentiation

Across TCGA cell cohorts, RNA activity of the Cerebral cortex GABAergic interneuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB43, VAC14, and MKLN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB43 grouped by Cerebral cortex GABAergic interneuron differentiation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RAB43 →	+0.831	+1.025	.002	.008	3	4
OESOPHAGUS	VAC14 →	-0.988	-1.584	<.001	<.001	3	3
SKIN	MKLN1 →	+0.501	+0.558	.001	.003	3	3
CNS	CDR2L →	-0.819	-0.859	.001	.001	3	3
LIVER	ENAH →	-1.215	-1.118	.003	.006	2	4
CNS	TMEM183A →	-0.427	-1.572	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB43 by Cerebral cortex GABAergic interneuron differentiation activity — BLOOD_Myeloma

Explore this box plot interactively →