Olfactory bulb interneuron differentiation

Across TCGA cell cohorts, RNA activity of the Olfactory bulb interneuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGBD2, ADIPOR2, and KIRREL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PGBD2 grouped by Olfactory bulb interneuron differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PGBD2 →	+0.892	+0.300	<.001	.004	2	4
LUNG_NSCLC_LUSC	ADIPOR2 →	-1.131	-1.236	<.001	.005	3	3
SKIN	KIRREL1 →	-0.761	-0.352	.003	.007	3	3
BLOOD_Leukemia	AKIRIN2 →	-0.805	-1.031	.006	.007	3	3
BREAST	ZNF860 →	+0.902	+0.986	.001	<.001	3	3
LUNG_SCLC	RBM17 →	+0.468	+0.246	.003	.004	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PGBD2 by Olfactory bulb interneuron differentiation activity — LUNG_SCLC

Explore this box plot interactively →