Forebrain cell migration

Across TCGA patient cohorts, RNA activity of the Forebrain cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT2, YME1L1, and MSRB3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain cell migration activity versus FERMT2 in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FERMT2 →	+0.492	+0.024	<.001	<.001	3	9
BRCA	YME1L1 →	-0.265	-0.023	.001	.001	3	8
UCEC	MSRB3 →	+0.649	+0.037	.001	.001	3	8
BRCA	PALLD →	+0.651	+0.036	<.001	<.001	3	8
CCRCC	PEAK1 →	+0.391	+0.045	<.001	<.001	3	8
CCRCC	RAB23 →	+0.377	+0.037	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021885 vs FERMT2 — BRCA

Explore this scatter interactively →