Forebrain cell migration

Across TCGA patient cohorts, RNA activity of the Forebrain cell migration pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A19, ESAM, and GUCY1A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain cell migration activity versus SLC25A19 in CCRCC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC25A19 →	-0.287	-0.392	.003	.008	3	4
CCRCC	ESAM →	+0.902	+0.686	<.001	.001	3	4
CCRCC	GUCY1A1 →	+0.558	+0.503	<.001	<.001	3	4
CCRCC	GNG12-AS1 →	+0.386	+0.647	.001	<.001	3	4
LSCC	FANCD2 →	-0.576	-0.436	<.001	<.001	3	4
LSCC	PRICKLE2 →	+0.554	+0.348	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021885 vs SLC25A19 — CCRCC

Explore this scatter interactively →