Forebrain neuron development

Across TCGA patient cohorts, RNA activity of the Forebrain neuron development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02475, LINC02884, and HMSD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain neuron development activity versus LINC02475 in CCRCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LINC02475 →	+0.610	+0.533	.001	.005	2	4
LUAD	LINC02884 →	+0.321	+0.529	.001	<.001	3	3
GBM	HMSD →	-0.505	-0.247	.004	.008	3	3
GBM	LINC02874 →	-0.048	-0.187	.006	.004	3	3
COAD	C3orf20 →	+0.142	+0.458	.001	.004	3	2
OV	FADS1 →	+0.874	+0.201	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021884 vs LINC02475 — CCRCC

Explore this scatter interactively →