Forebrain neuron development

Across TCGA cell cohorts, RNA activity of the Forebrain neuron development pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRMS1L, OGDH, and ZNF663P, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRMS1L grouped by Forebrain neuron development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	BRMS1L →	+0.131	+0.214	.001	.001	3	5
PANCREAS	OGDH →	-0.346	-0.229	.002	.002	2	6
STOMACH	ZNF663P →	-0.155	-0.312	.004	.008	3	5
SKIN	SSR1 →	+0.181	+0.292	.003	<.001	3	5
SKIN	PPP1R12A →	+0.277	+0.234	.009	.003	3	5
UPPER_AERODIGESTIVE_TRACT	PPP1R7 →	+0.234	+0.191	.002	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRMS1L by Forebrain neuron development activity — OESOPHAGUS

Explore this box plot interactively →