Forebrain neuron fate commitment

pathway activity — cross-omics
GO:0021877Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Forebrain neuron fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-F, FLT1P1, and MIR3907, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCHLA-F →-0.725-0.494.003.00134
COADFLT1P1 →-0.092-0.256.002.00234
CCRCCMIR3907 →+0.201+0.604.003<.00133
UCECFRMD6 →+0.724+0.200.002.00333
UCECTAL1 →+0.413+0.259.002<.00133
UCECKIF1B →+0.359+0.212.007.00233
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration