Forebrain generation of neurons

Across TCGA patient cohorts, RNA activity of the Forebrain generation of neurons pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDNRB, DIPK2B, and BCL6B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain generation of neurons activity versus EDNRB in CCRCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EDNRB →	+1.404	+0.489	<.001	<.001	3	6
CCRCC	DIPK2B →	+1.143	+0.813	<.001	<.001	3	6
CCRCC	BCL6B →	+1.037	+0.778	<.001	<.001	3	5
LSCC	SLC6A1-AS1 →	+0.272	+0.321	.007	.008	3	5
CCRCC	CLEC14A →	+1.453	+0.744	<.001	<.001	3	5
CCRCC	MYCT1 →	+1.104	+0.657	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021872 vs EDNRB — CCRCC

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