Forebrain regionalization

Across TCGA patient cohorts, RNA activity of the Forebrain regionalization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBX2_S360, PPIF, and HMCN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain regionalization activity versus TBX2_S360 in LUAD (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TBX2_S360 →	+0.565	+0.062	.001	<.001	3	7
LSCC	PPIF →	-0.438	-0.066	<.001	<.001	3	7
UCEC	HMCN1 →	+0.737	+0.126	<.001	<.001	3	7
OV	EVI2B →	-0.433	-0.062	.007	.001	3	6
BRCA	MKI67 →	-0.655	-0.043	.002	.003	3	6
HNSC	CTNND1 →	+0.210	+0.091	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021871 vs TBX2_S360 — LUAD

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