Forebrain regionalization

Across TCGA patient cohorts, RNA activity of the Forebrain regionalization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02542, METTL3, and ORC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain regionalization activity versus LINC02542 in OV (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LINC02542 →	-0.870	-0.570	<.001	.006	3	4
GBM	METTL3 →	+0.422	+0.253	<.001	.002	3	4
UCEC	ORC1 →	+0.850	+0.604	.001	.004	3	4
UCEC	DHPS →	+0.382	+0.426	.001	.009	3	4
UCEC	CDC20 →	+1.096	+0.541	.007	.004	3	4
OV	GLI3 →	+0.574	+0.527	.003	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021871 vs LINC02542 — OV

Explore this scatter interactively →