Forebrain regionalization

Across TCGA cell cohorts, RNA activity of the Forebrain regionalization pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYHR1, ST3GAL6, and PDZD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYHR1 grouped by Forebrain regionalization-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CYHR1 →	-0.419	-0.705	.001	.001	3	4
BLOOD_Leukemia	ST3GAL6 →	-2.091	-1.242	.009	<.001	3	4
KIDNEY	PDZD2 →	-1.912	-1.007	.002	.008	3	4
BLOOD_Lymphoma	MEIS1 →	-2.255	-1.728	<.001	<.001	3	3
BLOOD_Lymphoma	BRD7 →	+0.524	+1.581	.002	<.001	3	3
BLOOD_Lymphoma	CREM →	+1.496	+1.581	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYHR1 by Forebrain regionalization activity — SKIN

Explore this box plot interactively →