Forebrain radial glial cell differentiation

Across TCGA patient cohorts, RNA activity of the Forebrain radial glial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HTRA1, SHC2, and TRIM52-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain radial glial cell differentiation activity versus HTRA1 in LSCC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HTRA1 →	+0.553	+0.175	.001	.008	3	4
BRCA	SHC2 →	+0.932	+0.243	.003	.004	3	3
BRCA	TRIM52-AS1 →	+0.425	+0.252	.004	.006	3	3
BRCA	FNTB →	+0.309	+0.287	.001	.005	3	3
LSCC	EXTL3 →	+0.381	+0.237	.005	.008	3	3
HNSC	LEF1 →	+0.843	+0.538	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021861 vs HTRA1 — LSCC

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