Pyramidal neuron development

Across TCGA cell cohorts, RNA activity of the Pyramidal neuron development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLXNA3, ZMIZ1, and RALGDS, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyramidal neuron development activity versus PLXNA3 in KIDNEY (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PLXNA3 →	+2.128	+0.233	<.001	<.001	3	15
BONE	ZMIZ1 →	+1.707	+0.160	<.001	.002	2	15
LUNG_SCLC	RALGDS →	+1.071	+0.255	<.001	<.001	3	10
BLOOD_Myeloma	SCYL2 →	+0.902	+0.147	.003	.001	3	9
LUNG_SCLC	TRIM24 →	+1.069	+0.182	<.001	.001	3	8
BLOOD_Myeloma	RUFY2 →	+0.715	+0.137	.003	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021860 vs PLXNA3 — KIDNEY

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