Hypothalamus cell migration

Across TCGA patient cohorts, RNA activity of the Hypothalamus cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NRP2, PLOD3, and P4HA2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypothalamus cell migration activity versus NRP2 in CCRCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NRP2 →	+0.708	+0.089	<.001	<.001	3	7
BRCA	PLOD3 →	+0.425	+0.061	<.001	<.001	3	6
BRCA	P4HA2 →	+0.774	+0.073	<.001	.001	3	6
CCRCC	PLOD1 →	+0.504	+0.064	<.001	.004	3	6
COAD	COL12A1 →	+0.630	+0.063	.004	.002	3	5
COAD	CTHRC1 →	+0.960	+0.069	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021855 vs NRP2 — CCRCC

Explore this scatter interactively →