Hypothalamus cell migration

Across TCGA patient cohorts, RNA activity of the Hypothalamus cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRP1, TENM3, and MMP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypothalamus cell migration activity versus NRP1 in LSCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NRP1 →	+0.565	+0.313	<.001	.006	3	5
BRCA	TENM3 →	+0.875	+0.712	<.001	.001	3	4
UCEC	MMP2 →	+0.820	+0.288	.004	.008	2	5
LSCC	SEC24D →	+0.485	+0.363	<.001	.003	3	4
CCRCC	PLK3 →	+0.547	+0.634	<.001	<.001	3	4
CCRCC	C5AR1 →	+0.594	+0.547	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021855 vs NRP1 — LSCC

Explore this scatter interactively →