Hypothalamus cell migration

Across TCGA cell cohorts, RNA activity of the Hypothalamus cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NXF1, CYP2W1, and DHX38, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NXF1 grouped by Hypothalamus cell migration-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NXF1 →	-0.488	-0.161	.002	.003	2	5
SOFT_TISSUE	CYP2W1 →	-0.220	-0.273	<.001	.002	3	4
PANCREAS	DHX38 →	+0.309	+0.171	.002	.004	3	3
PANCREAS	GPSM1 →	+0.159	+0.144	.003	.005	3	3
PANCREAS	SHARPIN →	+0.234	+0.264	<.001	.001	3	3
PANCREAS	ARL15 →	+0.157	+0.178	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NXF1 by Hypothalamus cell migration activity — BREAST

Explore this box plot interactively →