Hypothalamus development

Across TCGA patient cohorts, RNA activity of the Hypothalamus development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NRP2, C1QC, and C1R, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypothalamus development activity versus NRP2 in BRCA (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NRP2 →	+0.484	+0.071	<.001	<.001	3	8
COAD	C1QC →	+0.374	+0.032	.002	.009	3	7
OV	C1R →	+0.551	+0.066	.005	.008	3	7
OV	FN1 →	+0.983	+0.068	.002	.004	3	7
LSCC	PPP1R18_S224 →	+0.661	+0.103	<.001	<.001	3	7
GBM	ARPC2 →	+0.176	+0.088	.004	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021854 vs NRP2 — BRCA

Explore this scatter interactively →