Hypothalamus development

Across TCGA cell cohorts, RNA activity of the Hypothalamus development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP7, CARD14, and MFSD13A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IGFBP7 grouped by Hypothalamus development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IGFBP7 →	-2.660	-0.933	<.001	.001	3	5
OESOPHAGUS	CARD14 →	+1.451	+1.151	.002	.001	3	5
LUNG_NSCLC_LUAD	MFSD13A →	+0.875	+0.886	<.001	.001	3	5
BONE	LGALS1 →	-6.527	-1.360	<.001	.007	3	5
BONE	CD151 →	-1.211	-1.252	.001	<.001	3	5
BONE	VIM →	-2.986	-1.198	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGFBP7 by Hypothalamus development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →