Hypothalamus development

Across TCGA cell cohorts, RNA activity of the Hypothalamus development pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2W1, NUDT11, and DLST, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP2W1 grouped by Hypothalamus development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CYP2W1 →	-0.249	-0.145	<.001	<.001	3	5
STOMACH	NUDT11 →	+0.113	+0.089	.003	.003	3	5
LUNG_SCLC	DLST →	-0.328	-0.159	.007	.004	3	4
BONE	MANBAL →	+0.285	+0.216	.009	<.001	3	4
BLOOD_Myeloma	ALX4 →	+0.182	+0.078	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ALLC →	-0.278	-0.290	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP2W1 by Hypothalamus development activity — SOFT_TISSUE

Explore this box plot interactively →