Hypothalamus development

Across TCGA cell cohorts, RNA activity of the Hypothalamus development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRP1, PLXNA3, and PLXNA1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypothalamus development activity versus NRP1 in OVARY (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NRP1 →	+2.475	+0.155	<.001	<.001	3	13
LUNG_NSCLC_LUSC	PLXNA3 →	+1.695	+0.221	<.001	.001	3	13
BLOOD_Leukemia	PLXNA1 →	+1.061	+0.066	<.001	<.001	3	11
LARGE_INTESTINE	IDS →	+1.140	+0.126	<.001	<.001	3	10
LUNG_NSCLC_LUAD	HPCAL1 →	+1.734	+0.191	<.001	<.001	3	10
LIVER	TGFBI →	+4.833	+0.191	.005	.009	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021854 vs NRP1 — OVARY

Explore this scatter interactively →