Cell proliferation in forebrain

Across TCGA patient cohorts, RNA activity of the Cell proliferation in forebrain pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPN11_Y542, PSIP1, and RAB10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell proliferation in forebrain activity versus PTPN11_Y542 in PDAC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PTPN11_Y542 →	+0.865	+0.047	<.001	<.001	3	5
GBM	PSIP1 →	+0.480	+0.044	.007	.005	3	5
CCRCC	RAB10 →	-0.160	-0.034	.004	.005	3	5
OV	RSU1 →	+0.356	+0.056	<.001	<.001	3	4
OV	SYTL4_S221 →	+1.315	+0.071	<.001	<.001	3	4
OV	TLN1 →	+0.275	+0.062	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021846 vs PTPN11_Y542 — PDAC

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