Cell proliferation in forebrain

Across TCGA patient cohorts, RNA activity of the Cell proliferation in forebrain pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02014, MOB4P2, and MIR26A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell proliferation in forebrain activity versus LINC02014 in COAD (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC02014 →	-0.500	-0.177	<.001	.002	3	4
GBM	MOB4P2 →	+0.452	+0.736	.001	.004	3	4
OV	MIR26A2 →	+0.607	+0.439	.008	<.001	3	3
LUAD	GPR85 →	-0.355	-0.369	<.001	.005	3	3
LUAD	TPP1 →	-0.266	-0.377	.008	.004	3	3
LUAD	ZDBF2 →	+0.471	+0.465	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021846 vs LINC02014 — COAD

Explore this scatter interactively →