Cell proliferation in forebrain

Across TCGA cell cohorts, RNA activity of the Cell proliferation in forebrain pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSR3, SLC25A51, and LYRM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SSR3 grouped by Cell proliferation in forebrain-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SSR3 →	-0.495	-0.953	.009	<.001	3	3
BLOOD_Leukemia	SLC25A51 →	-0.591	-0.965	.007	.008	3	3
BLOOD_Lymphoma	LYRM4 →	+1.062	+1.547	<.001	<.001	3	3
SKIN	GBF1 →	-0.330	-0.607	.003	.005	3	3
LUNG_NSCLC_LUSC	WNT2 →	-0.024	-1.701	.003	<.001	3	3
BREAST	CPED1 →	-0.991	-0.617	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SSR3 by Cell proliferation in forebrain activity — BLOOD_Leukemia

Explore this box plot interactively →