Cell proliferation in forebrain

Across TCGA cell cohorts, RNA activity of the Cell proliferation in forebrain pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HP1BP3, CCN1, and DDAH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell proliferation in forebrain activity versus HP1BP3 in BREAST (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HP1BP3 →	+0.682	+0.702	.005	.007	3	5
SOFT_TISSUE	CCN1 →	-2.882	-1.750	.007	.002	3	4
SOFT_TISSUE	DDAH1 →	-3.292	-2.052	.001	<.001	3	4
SKIN	CTNNAL1 →	-1.058	-1.002	<.001	.008	3	4
SOFT_TISSUE	MRPL33 →	-1.151	-1.779	.006	.003	2	4
BLOOD_Leukemia	ALDH1A2 →	+2.229	+0.461	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021846 vs HP1BP3 — BREAST

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