Substrate-independent telencephalic tangential migration

Across TCGA patient cohorts, RNA activity of the Substrate-independent telencephalic tangential migration pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLIT3, SORBS3, and CNRIP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Substrate-independent telencephalic tangential migration activity versus SLIT3 in OV (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLIT3 →	+0.628	+0.065	.008	.005	3	7
CCRCC	SORBS3 →	+0.396	+0.081	<.001	<.001	3	7
CCRCC	CNRIP1 →	+0.457	+0.077	<.001	<.001	3	7
CCRCC	FBLN1 →	+0.629	+0.108	<.001	<.001	3	7
CCRCC	LUM →	+0.684	+0.070	<.001	<.001	3	7
OV	MYLK →	+0.418	+0.049	.005	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021826 vs SLIT3 — OV

Explore this scatter interactively →