Substrate-independent telencephalic tangential migration

Across TCGA cell cohorts, RNA activity of the Substrate-independent telencephalic tangential migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFAT, CTXN1, and MLLT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZFAT grouped by Substrate-independent telencephalic tangential migration-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZFAT →	-2.003	-2.200	<.001	<.001	2	6
LUNG_SCLC	CTXN1 →	-2.214	-1.366	.001	.003	2	5
OESOPHAGUS	MLLT1 →	-0.565	-1.156	.001	<.001	3	4
LIVER	TEAD2 →	-1.851	-1.597	<.001	.007	3	4
URINARY_TRACT	RNF220 →	-1.290	-2.135	.003	.001	3	4
STOMACH	SKP2 →	-1.492	-1.373	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZFAT by Substrate-independent telencephalic tangential migration activity — BLOOD_Lymphoma

Explore this box plot interactively →