Substrate-independent telencephalic tangential migration

Across TCGA cell cohorts, RNA activity of the Substrate-independent telencephalic tangential migration pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR10G2, F8, and RALYL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR10G2 grouped by Substrate-independent telencephalic tangential migration-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR10G2 →	-0.262	-1.487	.002	<.001	3	4
KIDNEY	F8 →	+0.198	+1.818	.005	<.001	3	4
OESOPHAGUS	RALYL →	+0.145	+1.169	.001	.009	3	4
SOFT_TISSUE	CHST7 →	-0.268	-1.101	.004	.005	3	4
OVARY	IRAK3 →	+0.135	+0.940	.003	.004	3	3
LUNG_SCLC	POLN →	+0.295	+1.225	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR10G2 by Substrate-independent telencephalic tangential migration activity — OVARY

Explore this box plot interactively →