Layer formation in cerebral cortex

Across TCGA patient cohorts, RNA activity of the Layer formation in cerebral cortex pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH2D1A, PTPN6, and SEPTIN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Layer formation in cerebral cortex activity versus SH2D1A in BRCA (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SH2D1A →	-0.866	-0.054	<.001	<.001	3	7
LSCC	PTPN6 →	-0.340	-0.060	<.001	<.001	3	7
BRCA	SEPTIN1 →	-0.668	-0.054	<.001	<.001	3	7
LSCC	BIN2 →	-0.481	-0.071	<.001	<.001	3	7
LSCC	ARHGAP4 →	-0.363	-0.071	<.001	<.001	3	7
LSCC	CD38 →	-0.971	-0.081	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021819 vs SH2D1A — BRCA

Explore this scatter interactively →