Layer formation in cerebral cortex

Across TCGA patient cohorts, RNA activity of the Layer formation in cerebral cortex pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERG, DAB2IP, and BOK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Layer formation in cerebral cortex activity versus ERG in OV (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ERG →	+0.641	+0.297	<.001	.004	2	6
LSCC	DAB2IP →	+0.841	+0.706	<.001	<.001	3	4
LSCC	BOK →	+0.365	+0.395	.006	<.001	3	4
CCRCC	CASTOR1 →	+0.334	+0.337	<.001	.009	3	4
OV	LRCH2 →	+0.915	+0.294	.001	.008	3	4
GBM	AQP1 →	+1.558	+0.263	.001	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021819 vs ERG — OV

Explore this scatter interactively →