Cerebral cortex tangential migration

Across TCGA patient cohorts, RNA activity of the Cerebral cortex tangential migration pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL5A3, AFAP1_S548, and THY1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex tangential migration activity versus COL5A3 in HNSC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	COL5A3 →	+0.426	+0.072	.006	.007	3	7
OV	AFAP1_S548 →	+0.639	+0.056	.001	.004	2	7
OV	THY1 →	+0.527	+0.075	.004	<.001	3	6
CCRCC	CNN2 →	+0.528	+0.092	<.001	<.001	3	6
PDAC	MYH10 →	+0.385	+0.069	.004	.004	3	6
CCRCC	THBS2 →	+1.505	+0.097	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021800 vs COL5A3 — HNSC

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