Cerebral cortex tangential migration

Across TCGA patient cohorts, RNA activity of the Cerebral cortex tangential migration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ROBO1, RN7SL751P, and AP1G1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex tangential migration activity versus ROBO1 in GBM (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ROBO1 →	+0.592	+0.590	<.001	<.001	3	4
HNSC	RN7SL751P →	+0.843	+0.415	.001	.001	3	4
LSCC	AP1G1 →	-0.286	-0.465	.002	.001	3	4
GBM	NXN →	+0.528	+0.801	.006	.001	3	3
GBM	SEMA5A-AS1 →	+0.800	+0.646	.002	.002	3	3
COAD	DDX52 →	-0.480	-0.155	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021800 vs ROBO1 — GBM

Explore this scatter interactively →