Cerebral cortex radially oriented cell migration

Across TCGA patient cohorts, RNA activity of the Cerebral cortex radially oriented cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APOL3, SASH3, and WAS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex radially oriented cell migration activity versus APOL3 in HNSC (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	APOL3 →	-0.580	-0.037	<.001	.003	3	7
UCEC	SASH3 →	-0.492	-0.044	.004	.002	2	7
GBM	WAS →	-0.592	-0.055	<.001	<.001	3	6
GBM	CORO1A →	-0.593	-0.043	<.001	.006	3	6
GBM	CYBB →	-0.633	-0.047	<.001	.006	3	6
UCEC	DENND1C →	-0.470	-0.045	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021799 vs APOL3 — HNSC

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