Cerebral cortex regionalization

pathway activity — cross-omics
GO:0021796Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cerebral cortex regionalization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADGRG1, IL16, and APBB1IP_S526, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVADGRG1 →+0.575+0.125<.001<.00137
UCECIL16 →-0.488-0.143<.001.00136
PDACAPBB1IP_S526 →-0.286-0.095.004.00136
GBMSTAB1 →-0.473-0.091<.001<.00135
GBMCOPZ2 →-0.669-0.106<.001<.00135
UCECWAS →-0.470-0.137<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration