Cerebral cortex cell migration

Across TCGA patient cohorts, RNA activity of the Cerebral cortex cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MSRB3, PSME2, and PALLD, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex cell migration activity versus MSRB3 in BRCA (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MSRB3 →	+0.599	+0.024	<.001	<.001	3	7
HNSC	PSME2 →	-0.347	-0.054	.002	<.001	3	7
PDAC	PALLD →	+0.534	+0.045	<.001	<.001	3	7
BRCA	SEPTIN2 →	+0.180	+0.015	<.001	.009	3	6
GBM	SEPTIN7 →	+0.190	+0.044	.006	.003	3	6
BRCA	VCL_S795 →	+0.443	+0.023	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021795 vs MSRB3 — BRCA

Explore this scatter interactively →