Cerebral cortex cell migration

Across TCGA patient cohorts, RNA activity of the Cerebral cortex cell migration pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRICKLE2, VDR, and ZNF836, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex cell migration activity versus PRICKLE2 in CCRCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PRICKLE2 →	+0.481	+0.612	<.001	.004	3	5
LUAD	VDR →	+0.609	+0.424	<.001	<.001	3	4
CCRCC	ZNF836 →	+0.387	+0.496	<.001	.006	3	4
LSCC	KLF8 →	+0.509	+0.354	.001	.001	3	4
GBM	NTM →	+1.061	+0.994	<.001	<.001	3	4
CCRCC	IRAG1 →	+1.000	+0.680	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021795 vs PRICKLE2 — CCRCC

Explore this scatter interactively →