Cerebral cortex cell migration

Across TCGA cell cohorts, RNA activity of the Cerebral cortex cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MXRA7, ZRSR2, and LAMP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MXRA7 grouped by Cerebral cortex cell migration-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MXRA7 →	-1.271	-0.295	.001	.003	3	4
KIDNEY	ZRSR2 →	+0.664	+1.334	.008	.009	3	4
KIDNEY	LAMP3 →	+0.937	+1.172	.003	.001	3	4
BLOOD_Leukemia	RPL29 →	-0.582	-1.277	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ANTXR1 →	-1.940	-1.117	.006	.008	3	3
UPPER_AERODIGESTIVE_TRACT	CCDC151 →	-0.412	-1.288	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MXRA7 by Cerebral cortex cell migration activity — LUNG_SCLC

Explore this box plot interactively →