Cerebral cortex cell migration

Across TCGA cell cohorts, RNA activity of the Cerebral cortex cell migration pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAP1, SEMA7A, and GPD1L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebral cortex cell migration activity versus TRAP1 in SKIN (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TRAP1 →	-0.658	-0.262	<.001	.001	3	7
STOMACH	SEMA7A →	+2.352	+0.556	.001	.004	3	6
URINARY_TRACT	GPD1L →	-1.467	-0.356	.004	<.001	3	6
BLOOD_Leukemia	TTC7A →	+1.624	+0.550	<.001	.001	3	6
SOFT_TISSUE	MOB3C →	+0.647	+0.436	.004	<.001	3	6
SOFT_TISSUE	ANXA9 →	-0.621	-0.431	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021795 vs TRAP1 — SKIN

Explore this scatter interactively →