Branchiomotor neuron axon guidance

Across TCGA patient cohorts, RNA activity of the Branchiomotor neuron axon guidance pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL5A2, NUP88_S35, and COL1A2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branchiomotor neuron axon guidance activity versus COL5A2 in CCRCC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	COL5A2 →	+0.368	+0.056	.007	<.001	3	6
PDAC	NUP88_S35 →	+0.321	+0.067	.001	<.001	3	5
CCRCC	COL1A2 →	+0.377	+0.047	.005	.002	3	5
CCRCC	ARHGAP15_S64 →	-0.471	-0.075	.009	.001	3	5
LUAD	DOCK10_S1257 →	-0.870	-0.074	<.001	<.001	3	5
COAD	BRIX1 →	+0.216	+0.065	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021785 vs COL5A2 — CCRCC

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