Branchiomotor neuron axon guidance

Across TCGA patient cohorts, RNA activity of the Branchiomotor neuron axon guidance pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYCBP2, PKP2_S227, and MYCBP2_S3505, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branchiomotor neuron axon guidance activity versus MYCBP2 in LUAD (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MYCBP2 →	+0.259	+0.700	<.001	.001	3	8
BRCA	PKP2_S227 →	-0.732	-1.805	.001	<.001	3	3
PDAC	MYCBP2_S3505 →	+0.527	+0.897	<.001	<.001	3	3
LSCC	MYCBP2_T1625 →	+0.404	+0.474	.002	.001	3	3
GBM	MYCBP2_S181 →	+0.399	+0.551	<.001	.001	2	4
GBM	MYCBP2_S183 →	+0.399	+0.551	<.001	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021785 vs MYCBP2 — LUAD

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