Branchiomotor neuron axon guidance

Across TCGA cell cohorts, RNA activity of the Branchiomotor neuron axon guidance pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDF1, RDH14, and SDK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EDF1 grouped by Branchiomotor neuron axon guidance-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EDF1 →	+0.257	+0.211	.001	.002	3	4
PANCREAS	RDH14 →	-0.177	-0.172	.007	.008	3	4
BLOOD_Leukemia	SDK1 →	+0.113	+0.795	.009	.006	3	4
BLOOD_Leukemia	TLE2 →	+0.202	+0.875	<.001	.001	3	4
LARGE_INTESTINE	CDC42EP1 →	-0.182	-0.163	.002	.005	3	4
BLOOD_Myeloma	CSN3 →	-0.436	-1.752	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EDF1 by Branchiomotor neuron axon guidance activity — PANCREAS

Explore this box plot interactively →