Glial cell development

Across TCGA patient cohorts, RNA activity of the Glial cell development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1R, PCOLCE, and PYM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell development activity versus C1R in CCRCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	C1R →	+0.448	+0.024	<.001	<.001	3	7
CCRCC	PCOLCE →	+0.722	+0.021	<.001	.004	3	7
BRCA	PYM1 →	-0.248	-0.027	<.001	<.001	3	7
OV	VCAN →	+0.858	+0.031	.009	.004	3	6
OV	FSTL1 →	+0.623	+0.034	.004	.002	3	6
CCRCC	ORM1 →	+0.925	+0.038	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021782 vs C1R — CCRCC

Explore this scatter interactively →