Glial cell development

Across TCGA patient cohorts, RNA activity of the Glial cell development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFXN3, NKX3-2, and ZCCHC24, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell development activity versus SFXN3 in LSCC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SFXN3 →	+0.763	+0.488	.005	.001	3	7
LSCC	NKX3-2 →	+1.182	+0.391	.004	.001	3	7
LSCC	ZCCHC24 →	+1.141	+0.402	.001	.001	3	7
LSCC	C5orf46 →	+3.289	+0.570	.001	<.001	3	7
LSCC	SPARC →	+1.628	+0.450	<.001	<.001	3	7
BRCA	FEZ1 →	+0.585	+0.222	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021782 vs SFXN3 — LSCC

Explore this scatter interactively →