Glial cell development

Across TCGA cell cohorts, RNA activity of the Glial cell development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTK, YLPM1, and TTLL5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell development activity versus BTK in SKIN (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BTK →	-0.617	-0.175	.008	<.001	3	3
STOMACH	YLPM1 →	-1.067	-0.270	.003	<.001	3	3
STOMACH	TTLL5 →	-0.914	-0.248	.007	<.001	3	3
BREAST	PLPPR3 →	-1.430	-0.429	<.001	.009	3	3
STOMACH	GPR161 →	-2.527	-0.257	.001	<.001	3	3
STOMACH	IL17RD →	-1.126	-0.199	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021782 vs BTK — SKIN

Explore this scatter interactively →