Glial cell fate commitment

Across TCGA cell cohorts, RNA activity of the Glial cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE3B, RASSF4, and MAP7D1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDE3B grouped by Glial cell fate commitment-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PDE3B →	+1.347	+1.061	.004	.009	3	5
URINARY_TRACT	RASSF4 →	-2.237	-1.527	.001	<.001	3	4
LUNG_NSCLC_LUSC	MAP7D1 →	-1.280	-1.582	.001	<.001	3	4
BONE	NOL12 →	+0.641	+1.393	.008	<.001	3	4
OVARY	NETO2 →	+1.255	+1.088	.006	.006	3	4
SOFT_TISSUE	NABP1 →	-2.012	-0.968	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDE3B by Glial cell fate commitment activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →