Glial cell fate commitment

Across TCGA cell cohorts, RNA activity of the Glial cell fate commitment pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSD3, PKN2, and NAV3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NSD3 grouped by Glial cell fate commitment-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NSD3 →	-0.135	-1.339	<.001	<.001	3	4
BONE	PKN2 →	-0.228	-2.441	.002	<.001	3	4
LUNG_NSCLC_LUSC	NAV3 →	-0.235	-2.414	.001	<.001	3	4
OESOPHAGUS	DKC1 →	+0.323	+1.323	.002	.007	3	3
OESOPHAGUS	IPO8 →	-0.130	-2.422	<.001	<.001	3	3
OESOPHAGUS	RGS8 →	-0.278	-2.019	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NSD3 by Glial cell fate commitment activity — SKIN

Explore this box plot interactively →