Hippocampus development

Across TCGA patient cohorts, RNA activity of the Hippocampus development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFYB, NAT9, and NOL10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hippocampus development activity versus NFYB in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NFYB →	+0.459	+0.216	<.001	.001	3	4
COAD	NAT9 →	+0.342	+0.175	.009	.003	3	3
COAD	NOL10 →	+0.207	+0.162	.004	<.001	3	3
UCEC	RSAD1 →	+0.692	+0.117	.002	.006	3	3
CCRCC	LY6G5C →	+0.190	+0.604	.004	.008	3	3
BRCA	PWP1 →	+0.284	+0.208	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021766 vs NFYB — BRCA

Explore this scatter interactively →